Authors
Nicholus M Warstadt, Emily L Dennis, Neda Jahanshad, Omid Kohannim, Talia M Nir, Katie L McMahon, Greig I de Zubicaray, Grant W Montgomery, Anjali K Henders, Nicholas G Martin, John B Whitfield, Clifford R Jack Jr, Matt A Bernstein, Michael W Weiner, Arthur W Toga, Margaret J Wright, Paul M Thompson, Alzheimer's Disease Neuroimaging Initiative (ADNI
Publication date
2014/11/1
Journal
Neurobiology of aging
Volume
35
Issue
11
Pages
2504-2513
Publisher
Elsevier
Description
Several common genetic variants influence cholesterol levels, which play a key role in overall health. Myelin synthesis and maintenance are highly sensitive to cholesterol concentrations, and abnormal cholesterol levels increase the risk for various brain diseases, including Alzheimer's disease. We report significant associations between higher serum cholesterol (CHOL) and high-density lipoprotein levels and higher fractional anisotropy in 403 young adults (23.8 ± 2.4 years) scanned with diffusion imaging and anatomic magnetic resonance imaging at 4 Tesla. By fitting a multi-locus genetic model within white matter areas associated with CHOL, we found that a set of 18 cholesterol-related, single-nucleotide polymorphisms implicated in Alzheimer's disease risk predicted fractional anisotropy. We focused on the single-nucleotide polymorphism with the largest individual effects, CETP (rs5882), and found that …
Scholar articles
NM Warstadt, EL Dennis, N Jahanshad, O Kohannim… - Neurobiology of aging, 2014